|
KMID : 0616120060370040253
|
|
Korean Journal of Pharmacognosy
2006 Volume.37 No. 4 p.253 ~ p.257
|
|
|
Screening of Anti-angiogenic Activity from Plant Extracts
|
|
Kim Joon-Sik
Park Byoung-Young
Park Eun-Kyu
Lee Hee-Suk
Hahm Jong-Cheon
Bae Ki-Hwan
Kim Min-Young
|
|
|
Abstract
|
|
|
|
We examined anti-angiogenic effects of water extracts from 32 plant materials (20 Korean medicimal plants and 12 western herbs) using cell-based anti-angiogenic assay, HUVEC tube formation assy, and then we found that 7 plant extracts inhibited HUVEC tube formation strongly. The plant materials which showed anti-angiogenic effects are Cinnamomi Ramulus, Atractylodis Rhizoma alba, Polygalae Radix, Myristicae Semen, Artemisiae Iwayomogii Herba, leaves of Rosmarinus officinalis, and leaves of Melissa officinalis. We also investigated inhibitory effects of these anti-angiogenic herbal extracts on MMP(matrix metalloproteinase) activity which has important roles in angiogenesis. Among extracts tested in this study, water extract of Melissa officinalis showed the most potent anti-angiogenic and MMP inhibitory ativity.
|
|
|
KEYWORD
|
|
|
Angiogenesis, inhibitor, matrix metalloproteinase (MMP), HUVEC tube formation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|